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Pazopanib hydrochloride

CMI, dosage, igredients, description, price, photo

What is Votrient used for?

Votrient is an anti-cancer drug, of a type called protein kinase inhibitors.

Votrient is used as a single agent to treat kidney cancer that is advanced or has spread to other organs. It works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.

Votrient is also used as a single agent to treat Soft Tissue Sarcoma, a type of cancer that affects the supportive tissue of the body. It can occur in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs.

Your doctor may have prescribed Votrient for another reason.

This medicine is available only with a doctor's prescription.

Votrient is not addictive.

Before you take Votrient

Do not take if:

You must not take Votrient if:

  • you have ever had a severe allergic (hypersensitive) reaction to Votrient (pazopanib hydrochloride).
    Check with your doctor if you think this may apply to you.
  • you have ever had an allergic reaction to any of the ingredients listed toward the end of this leaflet.
    (See "Ingredients")
  • the expiry date (EXP) printed on the pack has passed.
  • the packaging is torn or shows signs of tampering.

Tell your doctor if:

Before you take Votrient your doctor needs to know if:

  • you have heart disease
  • you had heart failure or a heart attack
  • you have had prior blood clots in the vein or in a lung
  • you have had prior collapse of a lung
  • you have high blood pressure
  • you have liver disease
  • you have had problems with bleeding, blood clots or narrowing of the arteries
  • you have had stomach or bowel problems such as perforation (hole) or fistula (abnormal passages or tunnels leading out of the gut).
  • you have thyroid problems
  • you are going to have a surgical or dental procedure, or if you have had either recently.

Check with your doctor if you think any of these may apply to you.

Before you take Votrient, your doctor will take blood samples to check for any liver problems. You may need extra tests to check that your heart and thyroid are working properly. Your doctor may decide to adjust your dose or stop treatment based on the results of these tests.

Other medicines and Votrient

Tell your doctor or pharmacist if you are taking any other medicines, have taken any recently, or if you start new ones.

This includes herbal medicines and other medicines you've bought without a prescription.

Votrient can affect some other medicines, or they can affect Votrient. Taking both together can make it more likely that you'll have side effects. These medicines include:

  • clarithromycin, ketoconazole, itraconazole, rifampicin, telithromycin, voriconazole (used to treat infections)
  • atazanavir, indinavir, nelfinavir, ritonavir, saquinavir (used to treat HIV)
  • nefazodone (used to treat depression)
  • simvastatin (used to treat high cholesterol levels)
  • medicines that reduce stomach acid (e.g. esomeprazole)

Tell your doctor or pharmacist if you take any of these medicines. Some are not to be taken with Votrient. For others, the dose or the time you take the medicine may need to be changed.

Taking Votrient with food and drink

Votrient is affected by the food you eat. For details see How do I take Votrient?

Do not drink grapefruit juice while you are being treated with Votrient as this may increase the chance of side effects.

Pregnancy and breast-feeding

Votrient is not recommended if you are pregnant.

If you are pregnant, planning to get pregnant or think you might be pregnant, talk to your doctor about the risks and potential benefits of taking Votrient in pregnancy.

Use a reliable method of contraception to prevent pregnancy while you are taking Votrient.

Do not breast-feed while taking Votrient. It is not known whether the ingredients in Votrient pass into breast milk and so may harm your baby.

Talk to your doctor about this.

Driving and using machines

Votrient can have side effects such as fatigue, weakness and loss of energy that may affect your ability to drive.

Do not drive or use machines unless you're feeling well.

How do I take Votrient?

Always take Votrient exactly as your doctor has told you.

You should check with your doctor or pharmacist if you are not sure.

How much to take

The usual dose is 800 mg Votrient, taken once a day. Your doctor may decide to give you two 400 mg tablets or four 200 mg tablets to make up the 800 mg dose.

How to take it

Swallow the tablets whole with water, one after the other, at about the same time each day.

Do not break or crush the tablets as it affects the way the medicine is absorbed and may increase the chance of side effects.

It is important that you take Votrient either at least one hour before or at least two hours after food. Taking the drug with food increases the amount absorbed into the body, which may increase side effects.

Depending on your response to treatment, your doctor may recommend adjusting your dose or temporarily stopping your treatment.

If you forget to take Votrient

Do not take a double dose to make up for a missed dose. Take the next dose at the scheduled time.

How long to take it for

Take Votrient for as long as your doctor recommends. Do not stop unless your doctor advises you to.

What do I do if I take too much? (Overdose)

Immediately telephone your doctor or Poisons Information Centre (call 13 11 26) for advice if you think you or anyone else may have taken too much Votrient, even if there are no signs of discomfort or poisoning. If you are not sure what to do, contact your doctor or pharmacist.

While you are taking Votrient

While you are taking Votrient, your doctor will take blood samples to check for any liver problems. Your doctor will also take urine samples to check for any kidney problems. You will also have your blood pressure checked. Your doctor will periodically record your electrocardiogram (ECG) to check your heart's electrical conduction.

Your doctor will also check on any recent surgical or dental procedures to see if you are healing properly.

Things you must do

Tell your doctor if, for any reason, you have not taken your medicine exactly as directed.Otherwise, your doctor may think that it was not working as it should and change your treatment unnecessarily.

Things you must not do

Do not give this medicine to anyone else, even if their symptoms seem similar to yours.

Do not use Votrient to treat any other complaints unless your doctor says to.

What are the side effects?

Check with your doctor as soon as possible if you think you are experiencing any side effects or allergic reactions due to taking Votrient, even if the problem is not listed below.

Like all medicines, Votrient can cause side effects, although not everybody gets them. If they occur, they are most likely to be minor and temporary. However, some may be serious and need medical attention.

Very common side effects
These may affect more than 1 in 10 people:

  • diarrhoea
  • feeling or being sick (nausea or vomiting)
  • loss of appetite
  • stomach pain or discomfort
  • indigestion
  • high blood pressure
  • headache
  • loss of strength
  • lack of energy
  • weakness
  • changes in hair colour
  • weight loss
  • problems with taste
  • skin rash
  • scaly red skin rash
  • a skin reaction or pain on the palms of the hands or soles of the feet (including tingling, numbness, pain, swelling or reddening)
  • dizziness
  • cough
  • shortness of breath
  • chest pain
  • swelling of hands, ankles or feet
  • muscle pain
  • pain in the bones, muscles, ligaments, joints and tendons
  • mouth sores
  • unusual hair loss or thinning
  • loss of skin pigmentation

Very common side effect that may show up in your blood tests:

  • increase in some substances (enzymes) produced by the liver
  • protein in urine
  • under-active thyroid gland

Common side effects
These may affect up to 1 in 10 people:

  • heart becomes less effective at pumping blood (cardiac dysfunction)
  • changes in the heart's electrical conduction (QT-prolongation)
  • heart attack
  • severe bleeding in the lung
  • flatulence
  • nose bleed
  • dry skin
  • nail disorder
  • hoarseness
  • blurred vision
  • chills
  • blood in the urine
  • slow heart rate
  • sudden collapse of a lung, causing shortness of breath
  • muscle spasms
  • chest pain, shortness of breath, leg pain, and swelling of the legs/feet. These could be signs of a blood clot in your body (thromboembolism). If the clot breaks off, it may travel to your lungs and this may be life threatening or even fatal.

Common side effect that may show up in your blood or urine tests:

  • abnormal liver function
  • a decrease in the number of cells involved in blood clotting (thrombocytopenia)
  • low white blood cell count (neutropenia)
  • increase in bilirubin (a substance produced by the liver)
  • increase in gamma-glutamyl transpeptidase (a liver enzyme)
  • increase in albumin (a protein found in the blood)
  • increase in lipase (an enzyme from the pancreas)

Uncommon side effects
These may affect up to 1 in 100 people:

  • temporary reduction in blood supply to the brain (mini-stroke)
  • stroke
  • severe bleeding in digestive tract (stomach and intestine) and brain
  • reduction of blood supply to the heart (angina)
  • a dangerous rapid fluttering of the heart (Torsade de Pointes)
  • hole (perforation) in digestive tract
  • abnormal connection between parts of the digestive tract (fistula)
  • a sudden and severe rise in blood pressure which may be life-threatening
  • liver failure

Other side effects
Other side effects have occurred at an uncommon rate (these may affect up to 1 in 100 people):

  • infections, with or without changes in white blood cells (cells that fight infection)
  • inflammation of the pancreas
  • swelling of the brain that may be associated with high blood pressure, headache, loss of speech or vision, and/or seizure, which may be life threatening
  • separation or tear of the lining of the back part of the eye (retinal detachment or tear). This can result in blurry or impaired vision.

Other side effects have occurred, at a rare rate (these may affect up to 1 in 1,000 people):

  • blood clots accompanied by a decrease in red blood cells and cells involved in clotting. These clots may harm organs such as the brain and kidneys.
  • inflammation of the lung.

Tell your doctor immediately if you notice any of the following:

  • Wheezing, swelling of the lips/mouth, difficulty in breathing, hayfever, lumpy rash (hives) or fainting. These could be a symptom of an allergic reaction.

This is not a complete list of all possible side effects. Others may occur in some people and there may be some side effects not yet known.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

If you get side effects

Tell your doctor or pharmacist if any of the side effects listed become severe or troublesome, or if you notice any side effects not listed in this leaflet.

How do I store Votrient?

Keep this medicine where children cannot reach it, such as in a locked cupboard.

Do not store above 30°C.

Do not leave in a car, on a window sill or in a bathroom.

Do not use Votrient after the expiry date which is stated on the bottle.

Keep Votrient in its bottle until it's time to take it.


If you have any unwanted tablets don't put them in wastewater or household rubbish. Ask your pharmacist how to dispose of tablets you don't need.

This will help to protect the environment.

Product description

What Votrient looks like

Votrient are modified capsule-shaped, film coated tablets, available in plastic bottles with a child resistant closure.

  • 200 mg
    Pink tablets with 'GS JT' debossed on one side. Available in packs of 30 tablets and 90 tablets.
  • 400 mg
    White tablets with 'GS UHL' debossed on one side. Available in packs of 30 tablets and 60 tablets.


Votrient contains the active ingredient pazopanib hydrochloride. Each film-coated tablet contains the equivalent of either 200 mg or 400 mg pazopanib.

Votrient also contains:

  • cellulose - microcrystalline (E460)
  • povidone (E1201)
  • sodium starch glycolate
  • magnesium stearate (E572)
  • hypromellose (E464)
  • titanium dioxide (E171)
  • macrogol (E1521) Polysorbate 80
  • iron oxide red (E172) (200 mg tablets only).

Note: This information may not be actual at the time of reading. Always look for actual instructions in the package with the medication.
It is forbidden to use these materials without the advice of healthcare professional.

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