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Antidepressant medication drugs


Antidepressant - Oral. Tablets 25, 50 or 100mg


Zoloft is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, panic attacks, obsessive compulsive disorders (OCD), post-traumatic stress disorder (PTSD), social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder or PMDD).

Zoloft works by helping to restore the balance of certain natural chemicals in the brain.

OTHER USES: Zoloft has also been used to treat a type of decreased sexual ability (premature ejaculation) in men.

How to take this medication

Take Zoloft by mouth usually once daily with or without food; or as directed by your doctor. It is recommended that you take your dosage at the same time each day, either in the morning or in the evening.

Use Zoloft regularly in order to get the most benefit from it. The dosage is based on your medical condition and response to therapy.

It is important to continue taking Zoloft as prescribed even if you feel well. Do not stop taking this medication without consulting your doctor.

It may take up to 4 weeks before the full benefit of this drug takes effect.

Side effects

Nausea, dry mouth, increased sweating, drowsiness, diarrhea, upset stomach, or trouble sleeping may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed Zoloft because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur: uncontrollable shaking (tremor), loss of appetite, unusual weight loss.

Tell your doctor immediately if any of these unlikely but serious side effects occur: black stools, "coffee ground" vomit, decreased interest in sex, decrease in sexual ability (ejaculation delay), easy bruising/bleeding.

Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: unusual or rapid weight gain, unusual or severe mental/mood changes, seizures.

Males - in the unlikely event you experience a painful or prolonged erection, seek immediate medical attention as this is considered a medical emergency.

A very serious allergic reaction to Zoloft is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.

If you notice other effects not listed above, contact your doctor or pharmacist.


Before taking Zoloft, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

Before using Zoloft, tell your doctor or pharmacist your medical history, especially of: liver disease, seizures, heart disease, thyroid disease (e.g., hypothyroidism).

Zoloft may make you drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Avoid alcoholic beverages.

Though uncommon, depression can lead to thoughts or attempts of suicide. Tell your doctor immediately if you have any suicidal thoughts, worsening depression, or any other mental/mood changes (including new or worsening anxiety, agitation, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, rapid speech). Keep all medical appointments so your healthcare professional can monitor your progress closely and adjust/change your medication if needed.

Caution is advised when using Zoloft in the elderly because they may be more sensitive to the side effects of the drug. The elderly are more susceptible to developing a type of electrolyte imbalance (hyponatremia), especially if they are also taking "water pills" or diuretics with Zoloft.

Caution is advised when using Zoloft in children because they may be more sensitive to the side effects of the drug, especially loss of appetite and weight loss. It is important to monitor weight and growth in children who are taking Zoloft.

Zoloft should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

If Zoloft is used during the last 3 months of pregnancy, infrequently your newborn may develop symptoms including feeding or breathing difficulties, seizures, muscle stiffness, jitteriness, or constant crying. However, do not stop taking this medication unless your doctor directs you to do so. Report any such symptoms to your doctor promptly.

Zoloft passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug interactions

Certain medications taken with Zoloft could result in serious, even fatal, drug interactions. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before or after treatment with this medication. Consult your doctor or pharmacist for additional information.

Zoloft should also not be used with the following medications because very serious interactions may occur: pimozide, weight loss drugs (e.g., sibutramine, phentermine), tryptophan, terfenadine, astemizole, dihydroergotamine.

If you are currently using any of these medications, tell your doctor or pharmacist before starting Zoloft.

Before using Zoloft, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: ayahuasca, buspirone, carbamazepine, clozapine, dextromethorphan, flecainide, lithium, melatonin, meperidine, nefazodone, propafenone, other drugs which can cause bleeding/bruising (e.g., thrombolytic drugs such as TPA, anticoagulants such as heparin or warfarin, antiplatelet drugs including NSAIDs such as ibuprofen), other SSRI anti-depressants (e.g., citalopram, fluvoxamine), St. John's wort, thioridazine, tramadol, trazodone, tricyclic anti-depressants (e.g., amitriptyline), "triptan" migraine drugs (e.g., sumatriptan), venlafaxine.

Low-dose aspirin (usually 81-325 mg per day) for heart attack or stroke prevention should be continued unless your doctor instructs you otherwise. Aspirin is similar to NSAID drugs, and can increase the risk of bleeding in combination with Zoloft (see above). Discuss the risks and benefits with your doctor.

Other drugs besides Zoloft which may affect the heart rhythm (QTc prolongation in the EKG) include dofetilide, quinidine, sotalol, procainamide, and sparfloxacin among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Consult your doctor or pharmacist for details. Ask for instructions about whether you need to stop any other QTc-prolonging drugs you may be using in order to minimize the risk of this effect.

Tell your doctor if you take any drugs that cause drowsiness such as: anti-anxiety drugs (e.g., diazepam), antihistamines that cause drowsiness (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), tranquilizers.

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.


If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage from 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.


Note: This information may not be actual at the time of reading. Always look for actual instructions in the package with the medication.
It is forbidden to use these materials without the advice of healthcare professional.

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